Tasmanian devil genome mapping may help humans too

Maggie Lu-YueYang Reuters Yahoo News 17 Feb 12;

CANBERRA (Reuters) - Scientists have mapped the genome of Australia's endangered Tasmanian devil for the first time and found that deadly facial tumors decimating the species evolve very slowly, making it possible help might be found before the animals vanish forever.

Not only that, scientists at Australian National University said Friday that their discovery, published in the journal PLoS Genetics, could help untangle the process of how human cancers evolve.

Tasmanian devils -- popularized by Looney Tunes' fierce cartoon character "Taz" -- are carnivorous marsupials the size of a small dog. The facial tumor disease has ravaged the wild population, confined to Australia's island state of Tasmania, since being discovered in the mid-1990s.

Scientists believe that unless help is found, the wild population could be extinct within several decades.

But the mapping carried out by researchers led by Janine Deakin found that, at the genetic level, the tumors evolve very slowly, making it easier to study them -- and, possibly, circumvent them.

In addition, this may offer an unusual chance to study how human cancers develop, Deakin added.

"Because we find the devil tumor is evolving so slowly, we can use that as a model to look at cancers in humans. It is a bit more like slowing down the whole process in human cancers," she said.

"In human cancers the change happens so rapidly we don't have a chance to look into what the mechanisms are. And we can do that with the devil."

The Tasmanian devil tumor is spread by skin-to-skin contact and kills by deforming the animals, which then die through starvation or suffocation.

Deakin's team also found that significant fragments of the chromosomes in devils affected by the tumors had been jumbled, like a jigsaw puzzle put together the wrong way.

"One (chromosome) in particular has been completely shattered, which means genes are not in an appropriate order," Deakin said.

That discovery could lead to more avenues of investigation.

A previous U.S. study of two Tasmanian devils showed that the population already had low genetic diversity, which likely made them vulnerable to the cancer.

(Editing by Elaine Lies and Robert Birsel)

Tasmanian devils' killer disease genome mapped
Mark Kinver BBC News 17 Feb 12;

Researchers have sequenced the genome of the killer disease that is driving the remaining wild populations of Tasmanian devils towards extinction.

They hope the genetic data will offer clues on how to suppress the spread of Devil Facial Tumour Disease (DFTD), which is transmitted via biting.

Since DFTD was first recorded in 1996, populations in some areas are estimated to have declined by up to 90%.

Details of the research have been published in the journal Cell.

DFTD refers to a fatal condition that is characterised by the appearance of facial tumours.

As these develop into large cancerous growths, the animal finds it hard to eat. As it becomes weaker, it is unable to compete with other animals for food.

Researchers say that affected animals appear to die within three to five months of the lesions first appearing.

The international team of scientists that sequenced the genome (complete set of genetic material) of DFTD built on earlier work that sequenced the genome of the Tasmanian devil itself, and the combined work could play a role in preventing the continual spread of the contagious cancer.

"We can now look for mutated pathways that might be responsible for the cancer's growth, which may offer potential targets or ideas for therapeutic interventions that could help the devils in the wild," explained co-author Elizabeth Murchison, a researcher at the Wellcome Trust Sanger Institute, Cambridge, UK.

"It has also allowed us to identify a number of genes that have a number of mutations, which makes it different to a normal devil's genome," she told BBC News.

"Of course, we are also keen to develop vaccines that help the devils' bodies detect that the cancer is foreign, and by using these genes that are different between the cancer and the host, they may present ideas for developing vaccines."

'Immortal devil'

Dr Murchison added that the sequencing also allowed the researchers to understand the dynamics of the disease.

"Because the cancer is spread by living cancer cells, it actually arose from one individual devil," she said.

By using "genetic detective work", Dr Murchison and the team said the disease first arose in a female more than 15 years ago.

"As far as we know, it was just a normal, wild Tasmanian devil but for some reason it developed this tumour that became transmissible."

As the cancer cells were passed from one animal to another over the years, the original host was nicknamed the "immortal devil".

"She is, in a way, living on long after her own death," observed Dr Murchison.

Previous research revealed that DFTD was spread by biting, which played a major part in the devils' social interaction, such as mating and competing for food.

"Normally, a cancer that arises within the body of one person dies when that person dies," she explained. "It doesn't normally have an existence outside the body of its host.

"What is so unusual about the devils' cancer is that it has been able to survive after the death of its host.

"This has been facilitated by the fact that devils do bite each other, which has created a route for the transmission for the cancer."

The rapid spread of the contagious DFTD saw a steep decline in the wild population of the devils, prompting the Australian government in May 2009 to list the species (Sarcophilus harrisii) as Endangered.

As the world's largest marsupial carnivore is only found in the wild within Tasmania, the species is also listed as Endangered by the IUCN's global Red List of Threatened Species.

The outlook for the devils was so bleak that it prompted the government-backed Save the Tasmanian Devil Program to establish an "insurance population" in 2005.

This involved placing more than 270 disease-free devils in captivity in case it became necessary in the future to re-establish a healthy wild population.

But Dr Murchison added: "My goal is to do something to stop the spread of the disease in the wild before it is too late, [but] the wild population is declining at a very rapid rate, and there are some fears that the species in the wild could go extinct in 20-30 years.

"It would be impossible to re-introduce devils into the wild until we were certain that there were no diseased devils left out there, otherwise the [reintroduction] would be pointless because the disease would just come back again."

Explaining why it was important to continue research into developing a treatment for DFTD, she said: "Even if we do have to wait to re-introduce devils into the wild, it is going to be really important to be able to prevent those devils from getting the disease, and suppress the disease, just in case there are still reservoirs of it still left in the wild."