NEA, Alphabet Inc's Verily team up to fight dengue with AI

Cheryl Goh Channel NewsAsia 18 Sep 18;

SINGAPORE: The National Environment Agency’s (NEA) ongoing effort to suppress the urban Aedes aegypti mosquito population and fight dengue - Project Wolbachia - has received a technological boost.

NEA’s Environment Health Institute (EHI) announced on Tuesday (Sep 18) that it has teamed up with Verily (formerly named Google Life Sciences), the life sciences and healthcare company of US-based Alphabet Inc, to come up with an advanced, more efficient way to sort and release the male Wolbachia mosquitoes for Phase 2 of the field study.

The partnership was announced at the opening of the 5th Singapore International Dengue Workshop on Tuesday.

The sex-sorting technology uses artificial intelligence (AI) to accurately separate the males from the females. NEA currently uses a funnel-type device to separate them since female mosquitoes are larger than males. The AI sorting is less laborious and more accurate.

“Such a technology would prevent accidental release of female mosquitoes, which is important to ensure the effectiveness of the Wolbachia methodology in suppressing the urban Aedes mosquito population,” said NEA deputy chief executive officer Khoo Seow Poh.

Project Wolbachia uses Wolbachia-infected mosquitoes to suppress the Aedes aegypti mosquito population in Singapore. This is done because when male Wolbachia-infected mosquitoes mate with urban female Aedes aegypti mosquitoes, the eggs spawned do not hatch, resulting in a fall in the overall population.

Project Wolbachia uses Wolbachia-infected mosquitoes to suppress the Aedes aegypti mosquito population in Singapore. (Image: NEA)

Verily has also developed an automated release cart to dispense male Wolbachia mosquitos. It has been specially designed and tailored to fit into the lifts and long and narrow corridors of HDB blocks.

The cart is set to be tested at NEA’s Tampines West study site later this month.

For the trial, two carts will be deployed on the ground level and on higher floors - to ensure that the male Wolbachia mosquitoes are released more evenly.

With more of such male Wolbachia mosquitoes in the environment, there is a higher chance that the existing female Aedes aegypti will mate with them and lay sterile eggs, according to NEA.

Source: CNA/na(mn)

National Environment Agency to mass-produce mosquitoes for dengue control study
Linette Lai Straits Times 18 Sep 18;

SINGAPORE - Cutting-edge technology will be employed to mass-produce mosquitoes to make it easier for scientists to conduct research into ways to control dengue and other diseases.

The boffins need male mozzies, which do not feed on human blood, so they can inject them with a bacterium called Wolbachia.

These males are released and when they mate with females, the bacterium prevents the eggs from hatching, which in turn reduces the number of disease-carrying mozzies.

The Wolbachia study, as it is known, has been underway since 2016 and went up a gear in April with mosquitoes being released on higher floors in HDB blocks and at more frequent intervals.

The limiting factor has been getting enough males but a new initiative involving the National Environment Agency (NEA), local start-up Orinno Technology and Verily, a subsidiary of Google's parent company Alphabet, aims to make the process more efficient.

At present, producing mosquitoes on a large scale is a tedious undertaking.

Researchers have to count batches of larvae by hand and rely on manual methods to sort out males from the larger females, said Associate Professor Ng Lee Ching from the NEA's Environmental Health Institute.

They would then have to manually release batch after batch of mosquitoes at field testing sites.

"It's currently very labour-intensive," Prof Ng said, adding that the process is also subject to human error.

Adult mosquitoes, for example, may be weaker if they were overcrowded as larvae, or females may slip through the sorting process and affect the consistency of field experiments.

Prof Ng added: "If you want good quality mosquitoes, you must have very systemic production."

That is where the new initiative comes in. It harnesses a range of gadgets to inject more efficiency into the laborious process.

Orinno's technology can count 4,000 mosquitoes in three minutes, instead of the two hours a human would take.

And Verily's automated mosquito sex-sorter is hundreds of times more accurate than a human being, said Mr Nigel Snoad, product manager of the firm's Debug Project, which aims to use technology to improve the mosquito-rearing process.

Verily's automated cart is also designed to disperse Wolbachia-infected mosquitoes in a controlled manner while navigating narrow Housing Board flat corridors. The cart will be tested in Tampines West later this month in a trial that will end in January.

Mr Snoad added that Verily's technology has already been tested in the United States and Australia with good results, although this will be the first time that it will be used in a highly urbanised environment.

"We had to solve the challenge of how to get it in the lift and across the narrow corridors," he said.

The initiative was announced at the Singapore International Dengue Workshop, which started on Tuesday (Sept 18) and ends next week

NEA deputy chief executive Khoo Seow Poh said at the event: "Dengue has posed an enormous health and economic burden on many countries where resources and expertise are limited.

"This situation underscores the need for greater inter-sectoral collaboration to maximise the resources we have, to build more effective dengue control programmes."

Prof Ng also took the opportunity to give an update on the Wolbachia study, saying that results have been "very promising" so far.

"The overall aim is to see a suppressed population in the community," she said. "We will be monitoring the results, monitoring more data, and we hope to achieve that in the next few months."